Diagnostic de l’intoxication digitalique et son traitement. Ferrero C. Author affiliations. Clinique universitaire de Médecine Interne, Hôpital Cantonal, Genève . Request PDF on ResearchGate | Intoxication digitalique en période néonatale: rôle de la déshydratation | Background Despite the great progress which has. Request PDF on ResearchGate | Intoxication digitalique massive. Traitement par hémoperfusion sur résine Amberlite XAD 4 | Haemoperfusion over amberlite.

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You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted. Which decreases the sodic transmembrane gradient responsible for moving out calcium by the antiporter, while calcium continues to enter to the cell in each depolarization. Concepts of toxicokinetic-toxicodynamic modelling in clinical toxicology: Effect intkxication alterations of blood pH on digitalis toxicity.

Table 2 Drug Interactions of Digitalis. In fact, the intravenous lidocaine IV or phenytoin by either oral or intravenous controls effectively arrhythmias induced by the digitalis intoxication. Automatism disturbances To the ventricular floor it may consist of a ventricular extra systoles, more or less frequent, and tachycardia or ventricular fibrillation. This text will be overwritten by jQuery. Arch Mal Coeur Vaiss. N Engl J Med 6: The use of digoxin-specific Fab fragments for severe digitalis intoxication in patients.

The treatment is a temporary inhibition of digoxin under electrical supervision, a control of digoxinemia, monitoring and use of electrolytic supplements when needed. Eur J Nitoxication Pharmacol Clinical manifestations Digestive disorders, neurosensorial disorders and cardiovascular disorders are classically associated in clinical table of the digitalis intoxication.

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John Libbey Eurotext – Médecine thérapeutique – Intoxication aiguë par la digoxine

J Am Coll Cardiol In the presence of at least three pejorative factors: Digestive disorders Vomiting is the result of intocication excitatory action of digitalis glycosides on the postrema area. Correlation of serum magnesium levels and cardiac digitalis intoxication.

Treatment associated to low- risk situations will include temporary suspension of the therapy, ECG, follow-up and electrolytic supplements if necessary. We must as well monitor the symptoms. Post-countershock arrhythmias in untreated and digitalized dogs. Open in a separate window.

A prospective clinical study with serum level correlations. The next sodic influx. Role of hypoxia in digitalis toxicity. Associated Data Supplementary Materials. It is part of the arsenal therapeutic of atrial fibrillation, supraventricular tachycardia and congestive heart failure. Effect of the sympathetic tone regulation There is a direct effect of digitalis glycosides on the carotid baroreflex response to pressure variations diminished sensitivity in heart failure, might be restored by inhibition of the baroreceptors ATPaseinducing a decrease in the sympathetic tone.

Therefore, more calcium is stocked in the sarcoplasmic reticulum, where more calcium is available to the next cellular depolarization and increase in the myocardial contraction Figure 2. The margin between the therapeutic dose and the toxic one is very narrow, which requires the need for a regular monitoring especially a clinical one, particularly in case of elderly, renal failure and the risk of drugs associations Table 2.


Intensive Care Med Electrolyte and antiarrhythmic drug interaction. The latter may double in case of a renal failure. At higher concentrations, they increase the ventricular excitability. The digibind study advisory panel. Treatment of cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Headache, myalgia, asthenia are also frequent. The subcellular basis for the mechanism of inotropic action of cardiac glycosides.

Patients with severe renal impairment should be the subject of a prolonged follow up because it is not known with certainty if the inability to eliminate the antibody complex-digoxin may translate into a liberation of digoxin [6]. J Lab Clin Med. Thus, the digoxinemia may only be interpreted adequately few days after its administration.

Médecine thérapeutique

Allergic histories and reactions of patients treated with digoxin immune Fab ovine antibody. Contact Help Who are we?

The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to digitalque this data to third parties. Outline Masquer le plan. The cardiac complications often engage the vital prognosis imposing adequate support and quick response.

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